10 Health Problems Linked to Alzheimer’s Disease Years Before Diagnosis

Scientists aren’t sure if other symptoms are risk factors, the reason for developing the condition, or early warning signs that a person will develop it later in life

Early symptoms may be associated with Alzheimer's
Early symptoms may be associated with Alzheimer’s

Researchers have linked Alzheimer’s disease to 10 health conditions many years before diagnosis.

The earliest associated finding is major depressive disorder, identified nine years previously.

Anxiety, constipation and weight loss have also been linked to the brain condition leading to the shrinking of brain cells.

However, scientists aren’t sure if other symptoms are risk factors, the reason the condition develops, or early warning signs that a person will develop it.

Alzheimer’s causes memory loss, confusion and a deterioration in the ability to think over a long period of time.

And 70 percent of dementia Cases are thought to start with Alzheimer’s.

Anxiety, constipation, and weight loss have all been linked to Alzheimer’s


(Getty Images)

the daily record reports that researchers consider the disease to be one of the “most important public health challenges of the 21st century”.

Its cause is still unknown and currently there is no cure.

But the NHS says there are some well-established things that are thought to increase your risk of developing Alzheimer’s — such as: heart disease.

appear in The Lancet’s digital healthThe Paris Brain Institute aimed to confirm known risk factors for dementia and discover others.

The research could lead to early or new interventions in the devastating condition.

Scientists analyzed Alzheimer’s patient information and examined data collected from 20,214 UK patients for the study


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They analyzed Alzheimer’s patient information, examining data collected from 20,214 UK patients over a 24-year period and from 19,458 people in France over a 21-year period.

The study is the first to identify constipation as a possible risk factor, occurring seven years before Alzheimer’s diagnosis.

Health problems associated with subsequent Alzheimer’s diagnosis

  • Major depression
  • fear
  • constipation
  • Abnormal weight loss
  • response to severe stress
  • sleep disorders
  • deafness
  • Type of arthritis called cervical spondylosis
  • falls
  • fatigue

Researcher Thomas Nedelec of the Aramis team said: “The connections made allowed us to confirm known associations such as hearing problems or depression and other lesser known factors or early symptoms such as cervical spondylosis or constipation.

“However, we only report on statistical correlations. These need to be the subject of further studies to understand the underlying mechanisms.

“The question remains whether the health problems that have arisen are risk factors, symptoms or warning signs of the disease.”

In November last year The mirror reported a possible vaccine for the condition.

Experiments on mice found that the vaccine destroys rogue proteins in the brain, thereby restoring memory.

The supposedly groundbreaking therapy could revolutionize treatment, say British and German scientists.

Clinical trials of the technique, which targets soluble and highly toxic fragments of beta amyloid that clump together into plaques, could begin in two years.

And if a vaccine is successful, it could cost £15 a shot.

Professor Thomas Bayer of the University of Göttingen in Germany, who is a co-author of the study, said the scientists took a different approach.

They created antibodies that the immune system would not recognize as “foreign.”

Study co-author Professor Mark Carr of the University of Leicester then said: “If these findings were replicated in human studies, it could be transformative.

“It opens up the possibility of not only treating Alzheimer’s, but potentially also vaccinating against the disease before symptoms appear.”

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Fry Electronics Team

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