His video assistant will be Simon Hooper.
Madley last managed the Seagulls when they beat Manchester United 4-0 last season.
He has managed 17 Albion games since 2013 and the only loss in that span came when they were shocked 3-1 to Lincoln City in the FA Cup.
Madley last played at Anfield when Liverpool beat Cardiff in an FA Cup tie in February.
The full officiating team is as follows.
Referee: Andy Madley. Assistants: Derek Eaton, Steve Meredith. Fourth Official: Tony Harrington. VAR: Simon Hooper. VAR Assistant: Darren Cann.
https://www.theargus.co.uk/sport/22692314.andy-madley-referee-liverpool-v-brighton/?ref=rss Andy Madley directs Liverpool against Brighton