But head coach Roberto De Zerbi is confident Moises Caicedo will be fit.
Caicedo missed training yesterday due to an unknown issue.
It is believed the absence was precautionary and he was due to be examined this morning.
Speaking at a press conference this morning, De Zerbi said: “He wasn’t working with the team yesterday, but today we’re going to look at the situation.
“I think there will be no problem.”
Mwepu remains absent after suffering an illness with Zambia in Mali recently.
https://www.theargus.co.uk/sport/23030600.brighton-v-tottenham-de-zerbi-update-mwepu-caicedo/?ref=rss Brighton vs Tottenham: De Zerbi update on Mwepu, Caicedo