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Covid vaccines and ‘nocebo’ reactions: many ‘non-jab’ side effects

The majority of side effects associated with Covid vaccines are actually due to a phenomenon known as the “nocebo effect,” a newly published study found.

Described by The Independent is a “negative version of the placebo effect”, a nocebo reaction is when people report experiencing unpleasant side effects after receiving a “treatment with no pharmacological benefit”. physical”. And new research finds that factors including “anxiety, expectations and misattribution of various illnesses” such as headaches and fatigue are responsible for more than two-thirds of common side effects. . Vaccines against covid-19, speak Guardians.

Research published on Open Jama network The journal, based on data from 12 placebo-controlled clinical trials of Covid vaccines with a total of more than 45,000 people.

Although trial participants who received the vaccine actually had “significantly” more side effects, say researchers from the Beth Israel Deaconess Medical Center (BIDMC) in Boston, say researchers from the Beth Israel Deaconess Medical Center (BIDMC) in Boston. “. , Massachusetts.

After the first injection, 35% of the 22,578 placebo users experienced symptoms affecting their whole body, such as fever, while 16% reported “local adverse events.” , such as pain in the arm where the injection was given, and redness or swelling.

By comparison, 46% of the 22,802 vaccinated people actually experienced symptoms affecting their whole body after their first injection, and two-thirds reported at least one local event. direction.

But “while this group received active treatment with the actual vaccine, the researchers say that at least some of their reported side effects were due to the nocebo effect, as many of the same effects also occurred.” in the placebo group,” reported The Independent.

The scientists’ analysis showed that the nocebo effect accounted for 76% of all common adverse events after the first dose and nearly a quarter of all reported local adverse events.

After the second dose, reported adverse events were reduced to 32% in the placebo group, with 12% experiencing local events. However, side effect complaints increased to 61% in the remaining group, with 73% reporting topical side effects.

“The researchers suspect the higher rate of adverse events in the first-time vaccine group might make the participants more predictive the second,” the paper said.

Study co-author Ted J. Kaptchuk said listing in vaccine information leaflets about “non-specific” and “nocebo-sensitive” symptoms such as headache and fatigue could help explain Why do people report those side effects after the injection.

“Evidence suggests that this type of information can lead people to misallocate basic everyday sensations arising from vaccines or induce anxiety and anxiety that makes people overly alert to bodily sensations. about adverse events,” said Kaptchuk, program director at Harvard Medical, adding the university-affiliated BIDMC Teaching Hospital.

Co-author Julia W. Haas says that because concern about potential side effects is thought to be an important factor in vaccine hesitancy, analyzing nocebo responses is “critical for worldwide Covid-19 vaccination”.

https://www.theweek.co.uk/news/science-health/955454/placebo-study-majority-covid-vaccine-side-effects Covid vaccines and ‘nocebo’ reactions: many ‘non-jab’ side effects

Fry Electronics Team

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