Early screening could halve breast cancer deaths among young women

Annual MRI starting at 30 to 35 can reduce mortality by more than 50%. They will be offered to people with genetic mutations that increase the risk of the disease

Mammography
Early screening can be offered years before routine mammograms (Image available)

Early screening can cut numbers in half breast cancer Those who die in young women are vulnerable, according to a new study.

Scientists say annual magnetic resonance imaging (MRI) scans starting at 30 to 35 can reduce mortality by more than 50%.

They will be made available to people who have a genetic mutation that increases their risk of the disease – many years before the usual mammogram.

The mutations are called ATM, CHEK2 and PALB2 – and as dangerous as a famous faulty BRCA gene carries. Angelina Jolie.

Lead author, Dr Kathryn Lowry, University of Washington, Seattle, said: “Screening guidelines have been difficult to develop for these women because there are no clinical trials to inform when and how to initiate screening. filter.”







Breast cancer screening can save lives
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The findings were based on computer simulations using data from more than 32,000 patients and some women without similar breast cancer.

Dr Lowry said: “For women with pathogenic variants in these genes, our model analysis predicts a lifetime risk of developing breast cancer between 21% and 40%, depending depends on the variant.

“We project that starting annual MRI screenings between the ages of 30 and 35, with annual mammograms starting at age 40, will reduce cancer mortality for these groups of women more than 50%.”

The diagnosis was later found to double a young woman’s risk of spreading breast cancer.

Singer Girls Aloud Sarah Harding died of the disease last year. She is only 39 years old.







Sarah Harding dies aged 39
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Sarah Harding and Kimberley Walsh in 2012
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The study in the journal JAMA Oncology compared the combined performance of mammography and MRI compared with mammography alone.

It predicts that 12-month MRI screening provides significant additional benefit for these populations.

Dr Lowry said: “We also found that starting mammograms earlier than age 40 had no significant benefit but also increased false-positive screens.”

These are cases in which women are misinformed that they may have breast cancer – leading to anxiety and unnecessary biopsies.

Lead author, Professor Jeanne Mandelblatt, of the Georgetown Lombardi Comprehensive Cancer Center, said: “Modelling is a powerful tool for aggregating and scaling national cohort and clinical trial data to target clinical trials. estimate the benefits and harms of different cancer control strategies at population levels.”

The simulations predicted about four false-positive results and one to two benign biopsy results per woman over a 40-year screening period.

To realize the benefits of cancer screening guidelines based on genetic susceptibility, a woman needs to know she carries an associated variant before receiving a diagnosis.

Often genetic testing is done after someone has tested positive – too late to be of preventive value for the patient but potentially life-saving for blood relatives who can be found. Get genetic testing.

Lead author Dr Mark Robson, Director of Breast Health Services at Memorial Sloan Kettering Cancer Center, said: “People understand very well the value of testing for variants in BRCA1 and BRCA2, genes most common breast cancer predisposition.

“These results suggest that testing for other genes, such as ATM, CHEK2, and PALB2, may also help improve outcomes.”

Angelina Jolie had her breasts removed in 2013 because she carried the BRCA1 mutation that put her at high risk for breast cancer.







Angelina Jolie had her breasts removed in 2013
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She then had her ovaries and fallopian tubes removed to prevent ovarian cancer from developing. The terrible disease killed her mother at the age of 56.

The researchers hope the analysis will assist the National Comprehensive Cancer Network, the American Cancer Society and other organizations in providing guidelines for oncologists and radiologists.

Lead author Professor Allison Kurian, of Stanford University, California, added: “Overall, what we’re suggesting is screening a little earlier than what current guidelines suggest for a single one. number of women with these variants.

“For example, current NCCN guidelines recommend starting at age 30 for women with PALB2 and at age 40 for ATM and CHEK2.

“Our results suggest that starting MRI at age 30 to 35 appears to be beneficial for women with any of the three variants.”

Under the age of 35, the chance of a breast tumor moving or ‘metastasized’ to other parts of the body can increase by more than a third.







Approximately 2.3 million people worldwide are diagnosed with breast cancer each year
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In November, a global study found they were much more vulnerable than those over 50 who received regular screening.

Approximately 2.3 million people worldwide are diagnosed with breast cancer each year.

The NHS screening program that provides three mammograms annually to people over the age of 50. There have been calls to reduce the age limit.

Recent research shows that giving them to people over the age of 40 will prevent 300 deaths a year – mostly among younger women.

Breast cancer kills 685,000 women every year – including around 11,500 in the UK.

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https://www.mirror.co.uk/lifestyle/health/early-screening-could-halve-number-26260305 Early screening could halve breast cancer deaths among young women

Fry Electronics Team

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