Got a Covid Booster? You probably won’t need another one for a long time

Memory B cells become increasingly sophisticated over time, and they learn to recognize a wide range of viral genetic sequences. The longer they have to practice, the wider the range of virus variants they can contain.

Last year, researchers showed that the elite field inside the lymph nodes, where B cells train, called the germinal center, remains active for at least 15 weeks after the second dose of the Covid vaccine. In an updated study Published in the journal NatureThe same research group showed that six months after vaccination, the memory B cells continued to mature and the antibodies they produced continued to be able to recognize new variants.

Ali Ellebedy, an immunologist at Washington University in St. “Those antibodies at six months were better binders and more potent neutralizers than those produced one month after vaccination,” said Louis, who led the study.

In the latest study, another research team has shown that the third shot produces an even richer pool of B cells than the second shot, and that the antibodies they produce recognize a wide variety of variants. than. In laboratory experiments, these antibodies can work against Beta, Delta, and Omicron variants. In fact, more than half of the antibodies seen a month after the third dose could neutralize Omicron, even though the vaccine was not designed for that variant, the study found.

“If you have taken the third dose, you will have a quick response,” says Michel Nussenzweig. , an immunologist at Rockefeller University who led the study.

Memory cells produced after a coronavirus infection, but not a vaccine, appear to be less effective against the Omicron variant, base on the research was published last month in the journal Nature Medicine. Marcus Buggert, an immunologist at the Karolinska Institutet, Sweden, who led the study, said:

Although most people, vaccinated or not, only had a decrease in their T-cell response to Omicron, about one in five had a “significant decrease in response” by about 60 percent, Dr. Buggert said. The difference is most likely due to their basic genetic makeup, he said.

https://www.nytimes.com/2022/02/21/health/covid-vaccine-antibodies-t-cells.html Got a Covid Booster? You probably won’t need another one for a long time

Fry Electronics Team

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