A draw secures Portugal a place in the Nations League final while Spain make the leap across the Iberian border.
A surprise slip-up against Switzerland means Luis Enrique’s side need a win to have any hope of Group A2 victory.
The first meeting between the two in Seville ended in June.
Joao Cancelo could return to Fernando Santos’ side, while Enrique may opt for a change after struggling to show possession dominance against the Swiss.
Here’s everything you need to know before playing.
When and where is it?
The Portugal v Spain game kicks off at 7.45pm BST on Tuesday 27th September at the Estádio Municipal de Braga in Braga, Portugal.
How can I view it?
Viewers in the UK can watch the game live on BoxNation, with coverage starting at 19:35 BST. Premier Sports subscribers can stream the game through Premier Player.
Joao Cancelo missed Portugal’s win in the Czech Republic through suspension, giving Diogo Dalot a start and a starring role – the Manchester United full-back scored twice in the win, his first goals for his country. Cancelo’s return could then come at left-back, while Fernando Santos could also consider giving Cristiano Ronaldo a bench role after Dalot’s club-mate suffered a laceration to his face during the win.
Luis Enrique also didn’t add Dani Carvajal to his squad against Switzerland, but the right-back could return to Braga in place of Cesar Azpilicueta. Alvaro Morata could be used from the start to give Spain a more defined striker, while a reversal from Saturday to Tuesday could also see changes in midfield.
Portugal XI: costa; Dalot, Dias, Pereira, Cancelo; Neves, Palhinha, Fernandes; B. Silva, Ronaldo, Leao
Spain XI: Simon; Carvajal, Garcia, Torres, Alba; Koke, Rodri, Pedri; Torres, Morata, Arabia.
Portugal wins 11/8
Spain wins 12/5
This is unlikely to be a particularly open encounter with a Nations League finals spot at stake and the World Cup on the horizon. A draw would suit Portugal, who are strong defensively. Portugal 1-1 Spain
https://www.independent.co.uk/sport/football/portugal-spain-live-stream-online-b2175366.html Live stream Portugal vs Spain: How to watch Nations League game online and on TV