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Rate of myocarditis in vaccinated boys slightly higher than thought, results of Israeli study

Boys ages 12 to 15 have a small but increased risk of heart problems after a second dose of the Pfizer-BioNTech vaccine, Israeli researchers said Wednesday.

The study found that myocarditis, or inflammation of the heart muscle, occurred in 1 out of 12,361 boys this age within a week of the second dose.

Cases are mild, and side effects are still uncommon. Moreover, Several studies have shown that the risk of myocarditis after a Covid shot is much higher than after a vaccination.

However, Israel’s number is higher than the Centers for Disease Control and Prevention’s estimate of 1 case per 16,129 vaccinated adolescents aged 12 to 17. Israeli researchers previous report that nearly 11 out of 100,000 men aged 16 to 29 are at high risk of developing myocarditis after vaccination.

Although the results are only based on the Pfizer-BioNTech vaccine, other studies have found that the incidence of myocarditis may be higher with other mRNA vaccines manufactured by Moderna.

Several European countries have halted the use of the Moderna vaccine in teenage boys because of the risk. In the United States, only the Pfizer-BioNTech vaccine is approved for use in adolescents and children 5 years of age and older.

Concerns about inflammatory heart disease may have prompted the Food and Drug Administration to ask Pfizer-BioNTech and Moderna to enroll more children in their vaccine trials. Even so, Pfizer’s vaccine trial included only 567 boys aged 12 to 15 – too few to detect uncommon side effects.

The new study tracked hospitalizations for myocarditis from June 2, 2021 to October 20, 2021, through the Israeli Ministry of Health surveillance system. During that time, 404,407 adolescents aged 12 to 15 years received the first dose of the vaccine and 326,463 adolescents received the second dose.

The researchers found 18 reports of hospital admissions for myocarditis. The researchers said they excluded two of the cases because of “reasonable alternative diagnoses” and the other two because they occurred 46 and 70 days after the second dose – too long after the injection. Vaccine.

Of the remaining 14, one was an unvaccinated teenager, one was a teenager who received the first dose of vaccine less than a few weeks earlier, and 12 within a week of the second dose. two. The results were published in the New England Journal of Medicine.

All cases were clinically mild, and the adolescents were hospitalized for an average of three days. No content was read during the 30-day follow-up.

The researchers estimated that myocarditis occurred in 0.56 male adolescents per 100,000 after the first dose and 8.09 per 100,000 after the second dose. The corresponding risk in girls of that age was negligible.

The study may have underestimated the risk of myocarditis, because the researchers only looked at boys who were hospitalized for the condition. Myocarditis may present with chest pain, shortness of breath, and a feeling that the heart is racing, fluttering, or pounding. According to CDC.

https://www.nytimes.com/2022/01/26/health/myocarditis-israel-vaccine-study-boys.html Rate of myocarditis in vaccinated boys slightly higher than thought, results of Israeli study

Fry Electronics Team

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