“Scientists are studying whether blood type is linked to Covid severity” – Miriam Stoppard

The King’s College London findings could provide insight into potential new approaches to treating and preventing the most severe cases of coronavirus

Blood in a blood bag being checked before transfusion
Scientists are studying how blood type may be linked to the severity of Covid-19 in patients

In an effort to find factors that might favor Covid infection, researchers at King’s College London have analyzed over 3,000 proteins to see if any of them are causally linked to the development of severe Covid-19.

This is the first time such a large number of proteins have been analyzed for a possible link to Covid-19.

Importantly, the results can provide insight into potential new approaches to treating and preventing severe cases.

So far, researchers have identified eight proteins that could protect against severe Covid-19 and six that could increase the risk of a severe case.

One of the proteins, ABO, that increases the risk of developing severe Covid-19 also determines our blood types. So does your blood type decide whether you develop severe forms of the disease?

Blood group A is more common in Covid-19 positive patients


(Getty Images)

By examining this set of proteins, researchers have identified potential drug targets that could help treat severe Covid-19.

dr Alish Palmos, co-first author at King’s College London, says: “Using a purely genetic approach, we have looked at a large number of blood proteins and found that a handful have causal links to the development of severe Covid. The search for this group of proteins is an important first step in discovering potentially valuable targets for the development of new treatments.”

In addition, the scientists found eight proteins that protected against hospitalization or respiratory support/death and six that increased these risks.

They even distinguished between proteins associated with hospitalization and those associated with the need for ventilators.

The ABO enzyme, which determines blood type, was causally linked to both an increased risk of hospitalization and the need for a ventilator. This supports previous results of an association of blood groups with a higher probability of death.

Blood group A is more common in Covid-19 positive patients, suggesting that this blood group should be screened.

The research is really important



Professor Gerome Breen, co-first author and Professor of Genetics at King’s College London, says: ‘We shortlisted our study for the next phase of research.

“From thousands of blood proteins, we have reduced it to around 14 that have a causal link to the risk of severe Covid-19 disease and represent a potentially important avenue for further research to better understand the mechanisms behind the disease, with the ultimate goal.” to develop new treatments, but possibly also preventive therapies.”

The researchers also identified three “adhesion” molecules that are causally linked to a reduced risk of hospitalization.

Because these adhesion molecules mediate interactions between immune cells and blood vessels, this is consistent with previous research suggesting that late-stage Covid-19 is a disease involving the linings of blood vessels.

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Fry Electronics Team

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