The Real Health Podcast: Understanding the brain’s role in weight loss with Prof. Carel Le Roux


How much do you know about the relationship between our brain and our gut? While many of us think we choose when and how much we eat, research now tells us that our brain has far more control over our eating habits than we might realize.

o what does this mean for our understanding of obesity and what treatment is best for those affected?

Well this week I’m delighted to be joined by Carel La Roux, an expert in metabolic medicine and Professor of Experimental Pathology, University College Dublin.

Carel explains that helping people achieve their goals when it comes to losing weight takes more than willpower. The main reason for this is the power of the brain and its role in trying to hold on to body fat.

“Anyone who’s been on a diet will tell you they’ve never been more obsessed with food than when they’re on a diet. That’s normal physiology. That’s exactly what the brain needs to do… that’s normal.”

Carel says people, especially those with obesity, need to lose weight in order for the brain to be comfortable at a lighter weight. This is where, says Carel, modern treatments like medication and diet come into play.

We also discuss the signals the gut sends to the brain and how some people find it easier to keep their body weight down than others.

For more episodes, tips and advice from the series, see:

And you can contact me – I am @KarlHenryPT on Instagram and

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The Real Health Podcast is in partnership with Laya Healthcare The Real Health Podcast: Understanding the brain’s role in weight loss with Prof. Carel Le Roux

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