New research shows that some forms of paracetamol dissolved in carbonated water exceed patients’ recommended daily salt limit. Around 250 million packets of paracetamol are sold in the UK each year
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Some forms of pain relievers can be dissolved in carbonated water in excess of a patient’s recommended daily salt limit.
The international team of researchers followed 300,000 patients aged 60-90 between 2000 and 2017 from 790 GP surgeries in the UK.
Salt is used in some soluble paracetamol because it can encourage the breakdown of the tablet in water.
They found among those who have blood pressureThe risk of heart attack, stroke or heart failure within a year was 22% higher if they took paracetamol in its dissolved form.
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The overall risk was 5.6 percent compared with 4.6 percent in those taking sodium-free paracetamol, according to results published in the European Journal of Cardiology.
Among patients without high blood pressure, their one-year risk of developing cardiovascular disease was 19% higher if they took paracetamol with salt in it.
Professor Bruce Neal, of Imperial College London, who was not involved in the study, said: “The weight of evidence makes discontinuation for sodium-containing drugs untestable.
“The widespread use of effervescent drugs among the general population, and the enormous amounts of sodium that can be inadvertently consumed by unsuspecting consumers, call for urgent action.
“Particularly of concern are some surveys showing that up to 94% of carbonated drug users self-medicate using over-the-counter preparations.
“Immediate action is needed to protect consumers against these risks. The most logical and effective strategy may be to make it mandatory to label all drugs containing significant amounts of sodium with a warning label in front of the package.
“Information programs to raise public and physician awareness about potential sodium in drugs as well as educate about the need to avoid effervescent, dispersed, and soluble drugs in all settings.” necessary.”
Salt is widely used in medicines in the UK to make them more soluble.
Data from 2018 shows that 170 people per 10,000 of the population are using sodium-containing drugs. This rate is higher in women.
Around 250 million packets of paracetamol are sold in the UK each year.
Among those without high blood pressure, the one-year risk of cardiovascular disease was 4.4% in those taking salted paracetamol compared with 3.7% in those taking unsalted paracetamol.
The risk of death during follow-up was also higher in those taking paracetamol with salt.
The team, which includes researchers at Chinese universities, is calling for mandatory salt labeling on medicines.
Lead author, Professor Chao Zeng, Zhongnan University in Trường Sa, said: “Since the analgesic effect of sodium-free paracetamol is similar to that of sodium-containing paracetamol, clinicians may prescribe non-sodium paracetamol. sodium for them. patients to reduce the risk of cardiovascular disease and death.
“People should not only pay attention to the amount of salt in their food, but also should not overlook the hidden salt from medicines in their cupboards.
“Our results suggest a review of the safety profile of effervescent and soluble paracetamol.”
https://www.mirror.co.uk/lifestyle/health/warning-over-soluble-paracetamols-high-26311570 Warning about high levels of soluble salts in paracetamol can cause heart attacks